Engineered opsonin protein captures circulating tumor cells in the bloodstream with high efficiency
- Source:
- Wyss Institute for Biologically Inspired Engineering at Harvard
- Summary:
- Scientists have adapted an engineered human blood opsonin protein known as FcMBL, which was originally developed as a broad-spectrum pathogen capture agent, to target circulating tumor cells — the notoriously rare and difficult-to-locate agents of metastasis. Using magnetic beads coated with FcMBL, they were able to capture >90 percent of seven different types of cancer cells, demonstrating that the approach could be valuable in cancer diagnostics and monitoring.
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